Luc Devereaux, the only surviving member of the original Universal Soldier Team. He now works with Dylan Cotner, on a project to create and improve a new Universal Soldier. Their plan is for the Universal soldier or UNISOLS to be controlled by a computer they call SETH. When the government decides to terminate the project, which includes shutting down SETH. SETH, not wanting this to happen, takes steps to prevent this. He first kills Dylan. He then has himself transfered into a body. He then seeks out Luc Devereaux, who is the only person who knows the code that will stop his program from being deleted. So he sends out all the UNISOLS to get him. Luc must try and stay away until SETH program is deleted. But SETH has targeted his daughter as possible leverage.

The Law Enforcement Technology Advancement Centre (LETAC) has developed SID version 6.7: a Sadistic, Intelligent, and Dangerous virtual reality entity which is synthesized from the personalities of more than 150 serial killers. LETAC would like to train police officers by putting them in VR with SID, but they must prove the concept by using prisoners as test subjects. One such prisoner is ex-cop Parker Barnes. When SID manages to inject his personality into a nano-machine android, it appears that Barnes might be the only one who can stop him.